Toggle Accessibility Tools

Colloquium - Jingshu Wang

Institution: University of Chicago
Title: Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments
Date: October 5, 2021
Location: Zoom (Click here for meeting details)
Time: 10:20 AM - 11:10 AM Eastern Time

Abstract:
Mendelian randomization (MR) is a method of exploiting genetic variation to unbiasedly estimate a causal effect in presence of unmeasured confounding. In MR, natural genetic variations are used as instrumental variables to perform causal inference on the effect of heritable risk factors. Because of its convenience, MR has been being widely used in epidemiology and other related areas of population science. However, the phenomenon that “all genes affect every complex trait” complicates Mendelian Randomization (MR) studies as most genetic variants will then be invalid instruments.
In the talk, I’ll discuss the assumptions of existing MR methods and show how they need to be clarified to allow for pervasive horizontal pleiotropy and heterogeneous effect sizes. I’ll present a comprehensive framework that we have developed for MR. By using GWAS summary statistics, we can efficiently use both strong and weak genetic instruments, detect the existence of multiple pleiotropic pathways, determine the causal direction and perform multivariable MR to adjust for confounding risk factors. I’ll also illustrate a few case studies at the end of the talk.

Click here to view the colloquium flyer

news

July 22, 2021 MSU statistician attains uncommon Institute of Mathematical Statistics "Annals quadfecta" status

MSU statistician attains uncommon Institute of Mathematical Statistics "Annals quadfecta" status

June 24, 2021 STT presents William L. Harkness Award to PhD student

PhD student Nilanjan Chakraborty was recently presented with the William L. Harkness Award for outstanding teaching by a graduate student.

May 20, 2021 STT Undergraduate Student Andrew McDonald Awarded Goldwater Scholarship

Mr. Andrew McDonald, an Honors College junior majoring in Computer Science in the College of Engineering; and Statistics, and Advanced Mathematics in the College of Natural Science, has been named a recipient of the nationally competitive Barry M. Goldwater Scholarship.

upcoming events

Colloquium - Sam Pimentel

Institution: University of California, Berkeley
Title: [TBA]
Date: November 2, 2021
Location: Zoom (Click here for meeting details)
Time: 10:20 AM - 11:10 AM Eastern Time

Colloquium - Jordan Awan

Institution: Purdue University
Title: [TBA]
Date: November 16, 2021
Location: Zoom (Click here for meeting details)
Time: 10:20 AM - 11:10 AM Eastern Time

Colloquium - Edgar Dobriban

Institution: University of Pennsylvania
Title: [TBA]
Date: November 23, 2021
Location: Zoom (Click here for meeting details)
Time: 10:20 AM - 11:10 AM Eastern Time

Colloquium - Matthew Pratola

Institution: Ohio State University
Title: [TBA]
Date: November 30, 2021
Location: Zoom (Click here for meeting details)
Time: 10:20 AM - 11:10 AM Eastern Time