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Colloquium - Chad He

Institution: Fred Hutchinson Cancer Research Center
Title: Genetic Pathway Analysis Under High Dimensions
Date: September 29, 2020
Location: Zoom (Click here for meeting details)
Time: 10:20 AM - 11:10 AM Eastern Daylight Time (EDT)

Genetic pathway analysis has become an important tool for investigating the association between a group of genetic variants and traits. With dense genotyping and extensive imputation, the number of genetic variants in biological pathways has increased considerably and sometimes exceeds the sample size n. Conducting genetic pathway analysis and statistical inference in such settings is challenging. We introduce an approach that can handle pathways whose dimension p could be potentially greater than n. We establish the asymptotic distribution for the proposed statistic and conduct analysis on its power. Simulation studies show that our test performs well under the considered situations. An application to a genome-wide association study of high-density lipoproteins demonstrates the proposed approach.

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upcoming events

Colloquium - Vladimir Koltchinskii

Institution: Georgia Institute of Technology
Title: Bias reduction and efficiency in estimation of smooth functionals of high-dimensional parameters
Date: October 27, 2020
Location: Zoom
Time: 10:20 AM - 11:10 AM Eastern Daylight Time (EDT)


Colloquium - Ian McKeague

Institution: Columbia University
Title: Significance testing for canonical correlation analysis in high dimensions
Date: November 3, 2020
Location: Zoom
Time: 10:20 AM - 11:10 AM Eastern Standard Time (EST)


Colloquium - Lin Chen

Institution: University of Chicago
Title: Integrative Genomic Association and Mediation Analysis
Date: November 10, 2020
Location: Zoom
Time: 10:20 AM - 11:10 AM Eastern Standard Time (EST)


Colloquium - Eric Chi

Institution: North Carolina State University
Title: [TBA]
Date: November 17, 2020
Location: Zoom
Time: 10:20 AM - 11:10 AM Eastern Standard Time (EST)